Talking to your patients about Ozempic® (semaglutide) injection
Pharmacists, patients may have questions when they pick up their prescription of Ozempic®. Here are some topics you may want to discuss with them.
EXPERIENCE MATTERS
Review the history and see milestones Ozempic® has achieved being prescribed to patients with T2D.
What is Ozempic®?
- Ozempic® is a once-weekly human glucagon-like peptide-1 (GLP-1) receptor agonist
- Ozempic® is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus and to reduce the risk of major adverse cardiovascular (CV) events (CV death, nonfatal myocardial infarction, or nonfatal stroke) in adults with type 2 diabetes mellitus and established CV disease
See Section 17: Patient Counseling Information in the Prescribing Information
Limitations of Use
- Ozempic® has not been studied in patients with a history of pancreatitis. Consider other antidiabetic therapies in patients with a history of pancreatitis.
- Ozempic® is not indicated for use in patients with type 1 diabetes mellitus.
aThe starting dose of 0.25 mg is a nontherapeutic dose.
- Administer Ozempic® once weekly on the same day each week, at any time of the day, with or without meals
- The maximum recommended dosage is 2 mg once weekly
- The day of weekly administration can be changed if necessary as long as the time between 2 doses is at least 2 days (>48 hours)
- If a dose is missed, administer Ozempic® as soon as possible within 5 days after the missed dose. If more than 5 days have passed, skip the missed dose and administer the next dose on the regularly scheduled day. In each case, patients can then resume their regular once-weekly dosing schedule
Savings are available for eligible patients
Pen that delivers doses of 0.25 and 0.5 mg
Contains 2 mg of Ozempic®
Delivers only the starting dose of
0.25 mg and a maintenance dose of 0.5 mg
Pen that delivers doses of 1 mg
Contains 4 mg of Ozempic®
Delivers only the maintenance dose of 1 mg
Pen that delivers doses of 2 mg
Contains 8 mg of Ozempic®
Delivers only the maximum maintenance dose of 2 mg
Thinnest once-weekly GLP-1 RA needle (32G, 4 mm) included with each pen1
Order today
How to store the Ozempic® Pen1
Prior to first use
Until expiration date
Refrigerated
36°F to 46°F (2°C to 8°C)
After first use
56 days
Room Temperature
59°F to 86°F (15°C to 30°C)
Refrigerated
36°F to 46°F (2°C to 8°C)
How to dispense Ozempic®1
Ozempic® 0.25 mg or 0.5 mg dose
(2 mg/3 mL subcutaneous pen injector)
NDC: 0169-4181-13
Days supply:
• Sample/initial (42 days)
• 1-month supply (28 days)
Intent of prescription:
• Sample or initial prescription for new starts
• 1-month prescription for maintenance on 0.5 mg
Strength: 2 mg per 3 mL (0.68 mg/mL)
Dosage form: Solution
SIG:
• Sample or initial Rx: Inject 0.25 mg SC once weekly for 4 weeks, then 0.5 mg SC once weekly for 2 weeks
• Maintenance Rx: Inject 0.5 mg SC once weekly for 4 weeks
Dispense quantity: 3 mL
Dispense quantity unit of measure: mL ONLY
Needles: 6 included
Number of boxes: 1 box
Ozempic® 0.25 mg or 0.5 mg dose
(2 mg/3 mL subcutaneous pen injector)
NDC: 0169-4181-13
Days supply:
3-month supply (84 days)
Intent of prescription:
3-month prescription for maintenance on 0.5 mg
Strength: 2 mg per 3 mL (0.68 mg/mL)
Dosage form: Solution
SIG: Maintenance Rx: Inject 0.5 mg SC once weekly for 12 weeks
Dispense quantity: 9 mL
Dispense quantity unit of measure: mL ONLY
Needles: 18 included
Number of boxes: 3 boxes
Ozempic® 1 mg dose
(4 mg/3 mL subcutaneous pen injector)
NDC: 0169-4130-13
Days supply:
1-month supply (28 days)
Intent of prescription:
1-month prescription for maintenance on 1 mg
Strength: 4 mg per 3 mL (1.34 mg/mL)
Dosage form: Solution
SIG:
Maintenance Rx: Inject 1 mg SC once weekly for 4 weeks
Dispense quantity: 3 mL
Dispense quantity unit of measure: mL ONLY
Needles: 4 included
Number of boxes: 1 box
Ozempic® 1 mg dose
(4 mg/3 mL subcutaneous pen injector)
NDC: 0169-4130-13
Days supply:
3-month supply (84 days)
Intent of prescription:
3-month prescription for maintenance on 1 mg
Strength: 4 mg per 3 mL (1.34 mg/mL)
Dosage form: Solution
SIG: Maintenance Rx: Inject 1 mg SC once weekly for 12 weeks
Dispense quantity: 9 mL
Dispense quantity unit of measure: mL ONLY
Needles: 12 included
Number of boxes: 3 boxes
Ozempic® 2 mg dose
(8 mg/3 mL subcutaneous pen injector)
NDC: 0169-4772-12
Days supply:
1-month supply (28 days)
Intent of prescription:
1-month prescription for maintenance on 2 mg
Strength: 8 mg per 3 mL (2.68 mg/mL)
Dosage form: Solution
SIG:
Maintenance Rx: Inject 2 mg SC once weekly for 4 weeks
Dispense quantity: 3 mL
Dispense quantity unit of measure: mL ONLY
Needles: 4 included
Number of boxes: 1 box
Ozempic® 2 mg dose
(8 mg/3 mL subcutaneous pen injector)
NDC: 0169-4772-12
Days supply:
3-month supply (84 days)
Intent of prescription:
3-month prescription for maintenance on 2 mg
Strength: 8 mg per 3 mL (2.68 mg/mL)
Dosage form: Solution
SIG: Maintenance Rx: Inject 2 mg SC once weekly for 12 weeks
Dispense quantity: 9 mL
Dispense quantity unit of measure: mL ONLY
Needles: 12 included
Number of boxes: 3 boxes
More ways to help your patients with T2D
Important Safety Information for Ozempic® (semaglutide) injection
WARNING: RISK OF THYROID C-CELL TUMORS
- In rodents, semaglutide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures. It is unknown whether Ozempic® causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans as human relevance of semaglutide-induced rodent thyroid C-cell tumors has not been determined.
- Ozempic® is contraindicated in patients with a personal or family history of MTC and in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Counsel patients regarding the potential risk for MTC with the use of Ozempic® and inform them of symptoms of thyroid tumors (eg, a mass in the neck, dysphagia, dyspnea, persistent hoarseness). Routine monitoring of serum calcitonin or using thyroid ultrasound is of uncertain value for early detection of MTC in patients treated with Ozempic®.
Indications and Limitations of Use
Ozempic® (semaglutide) injection 0.5 mg, 1 mg, or 2 mg is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus and to reduce the risk of major adverse cardiovascular (CV) events (CV death, nonfatal myocardial infarction, or nonfatal stroke) in adults with type 2 diabetes mellitus and established CV disease.
- Ozempic® has not been studied in patients with a history of pancreatitis. Consider other antidiabetic therapies in patients with a history of pancreatitis.
- Ozempic® is not indicated for use in patients with type 1 diabetes mellitus.
Important Safety Information cont.
Contraindications
- Ozempic® is contraindicated in patients with a personal or family history of MTC or in patients with MEN 2, and in patients with a hypersensitivity reaction to semaglutide or to any of the excipients in Ozempic®. Serious hypersensitivity reactions including anaphylaxis and angioedema have been reported with Ozempic®.
Warnings and Precautions
- Risk of Thyroid C-Cell Tumors: Patients should be referred to an endocrinologist for further evaluation if serum calcitonin is measured and found to be elevated or thyroid nodules are noted on physical examination or neck imaging.
- Pancreatitis: Acute and chronic pancreatitis have been reported in clinical studies. Observe patients carefully for signs and symptoms of pancreatitis (persistent severe abdominal pain, sometimes radiating to the back with or without vomiting). If pancreatitis is suspected, discontinue Ozempic® promptly, and if pancreatitis is confirmed, do not restart.
- Diabetic Retinopathy Complications: In a 2-year trial involving patients with type 2 diabetes and high cardiovascular risk, more events of diabetic retinopathy complications occurred in patients treated with Ozempic® (3.0%) compared with placebo (1.8%). The absolute risk increase for diabetic retinopathy complications was larger among patients with a history of diabetic retinopathy at baseline than among patients without a known history of diabetic retinopathy.
Rapid improvement in glucose control has been associated with a temporary worsening of diabetic retinopathy. The effect of long-term glycemic control with semaglutide on diabetic retinopathy complications has not been studied. Patients with a history of diabetic retinopathy should be monitored for progression of diabetic retinopathy. - Never Share an Ozempic® Pen Between Patients: Ozempic® pens must never be shared between patients, even if the needle is changed. Pen-sharing poses a risk for transmission of blood-borne pathogens.
- Hypoglycemia: Patients receiving Ozempic® in combination with an insulin secretagogue (eg, sulfonylurea) or insulin may have an increased risk of hypoglycemia, including severe hypoglycemia. Inform patients using these concomitant medications of the risk of hypoglycemia and educate them on the signs and symptoms of hypoglycemia.
- Acute Kidney Injury: There have been postmarketing reports of acute kidney injury and worsening of chronic renal failure, which may sometimes require hemodialysis, in patients treated with GLP-1 receptor agonists. Some of these events have been reported in patients without known underlying renal disease. A majority of the reported events occurred in patients who had experienced nausea, vomiting, diarrhea, or dehydration. Monitor renal function when initiating or escalating doses of Ozempic® in patients reporting severe adverse gastrointestinal reactions.
- Hypersensitivity: Serious hypersensitivity reactions (eg, anaphylaxis, angioedema) have been reported in patients treated with Ozempic®. If hypersensitivity reactions occur, discontinue use of Ozempic®; treat promptly per standard of care, and monitor until signs and symptoms resolve. Use caution in a patient with a history of angioedema or anaphylaxis with another GLP-1 receptor agonist.
- Acute Gallbladder Disease: Acute events of gallbladder disease such as cholelithiasis or cholecystitis have been reported in GLP-1 receptor agonist trials and postmarketing. In placebo-controlled trials, cholelithiasis was reported in 1.5% and 0.4% of patients treated with Ozempic® 0.5 mg and 1 mg, respectively, and not reported in placebo-treated patients. If cholelithiasis is suspected, gallbladder studies and appropriate clinical follow-up are indicated.
Adverse Reactions
- The most common adverse reactions, reported in ≥5% of patients treated with Ozempic® are nausea, vomiting, diarrhea, abdominal pain, and constipation.
Drug Interactions
- When initiating Ozempic®, consider reducing the dose of concomitantly administered insulin secretagogue (such as sulfonylureas) or insulin to reduce the risk of hypoglycemia.
- Ozempic® causes a delay of gastric emptying and has the potential to impact the absorption of concomitantly administered oral medications, so caution should be exercised.
Use in Specific Populations
- There are limited data with semaglutide use in pregnant women to inform a drug-associated risk for adverse developmental outcomes. Discontinue Ozempic® in women at least 2 months before a planned pregnancy due to the long washout period for semaglutide.
Please click here for Ozempic® Prescribing Information, including Boxed Warning.
Reference:
- Ozempic® [package insert]. Plainsboro, NJ: Novo Nordisk Inc.; October 2022.