Acquired hemophilia is a rare condition that appears spontaneously
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Acquired hemophilia is a rare condition that appears spontaneously
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In acquired hemophilia, antibodies or inhibitors develop against the body’s own coagulation factor, frequently factor FVIII. Acquired hemophilia (AH) appears spontaneously in people who were not born with hemophilia. Patients may have underlying conditions, but often do not.1-3
Acquired hemophilia is:
Extremely rare— affecting only 1.5 per million people annually4
Challenging to diagnose—nearly 52% of cases are idiopathic3
Potentially fatal—up to 21% mortality rate5
Diagnosis time matters
Acquired hemophilia can be fatal. Knowing how to spot the signs and symptoms is vital, so that critical laboratory tests can be performed and a diagnosis can be made.
Diagnosis time matters
Acquired hemophilia can be fatal. Knowing how to spot the signs and symptoms is vital, so that critical laboratory tests can be performed and a diagnosis can be made.
![Infographic stating 35% of patients go undiagnosed for more then 7 days [Reference 3]](/rare-bleeding-disorders/hcp-education/clinical/acquired-hemophilia/overview/_jcr_content/root/slab_90018005/content/image.img.svg/1644362727589/chart-35-percent.svg)
![Infographic stating 70% of patients experience severe or life-threatening bleeding [Reference 3]](/rare-bleeding-disorders/hcp-education/clinical/acquired-hemophilia/overview/_jcr_content/root/slab_90018005/content/image_copy.img.svg/1644362760380/chart-70-percent.svg)
What makes acquired hemophilia difficult to diagnose?
Acquired hemophilia is extremely rare, so many health care providers may have never diagnosed a patient with AH. Patients may present with a variety of underlying conditions (or none at all); in addition, AH is associated with a bimodal age distribution.3
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AH patients with an underlying condition3
AH patients by underlying condition3,a
aSome patients may have more than one associated disease.
Adapted with permission from Knoebl et al.3
Age and sex distribution of patients with acquired hemophilia3
Adapted with permission from Knoebl et al.3
Review the signs of acquired hemophilia
See the common signs and symptoms of acquired hemophilia, and how patients typically present with this rare bleeding disorder.
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Explore acquired hemophilia education
Watch videos and listen to presentations covering clinical features, diagnosis and treatment of acquired hemophilia.
References:
- Tiede A, Collins P, Knoebl P, et al. International recommendations on the diagnosis and treatment of acquired hemophilia A. Haematologica. 2020;105(7):1-16.
- National Hemophilia Foundation. MASAC recommendations concerning products licensed for the treatment of hemophilia and other bleeding disorders, #263. New York, NY: National Hemophilia Foundation; 2020.
- Knoebl P, Marco P, Baudo F, et al; EACH2 Registry Contributors. Demographic and clinical data in acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2). J Thromb Haemost. 2012;10(4):622-631.
- Kruse-Jarres R, Kempton C, Baudo F et al. Acquired hemophilia A: Updated review of evidence and treatment guidance. Am J Hematol. 2017;92:695–705
- Bitting RL, Bent S, Li Y, Kohlwes J. The prognosis and treatment of acquired hemophilia: a systematic review and meta-analysis. Blood Coagul Fibrinolysis. 2009;20(7):517-523.